GlutaredoxinV1, Main, Exploration, bibRecord, 000C02

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

Identifieur interne : 000C02 ( Main/Exploration ); précédent : 000C01; suivant : 000C03

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

Auteurs : Attila Kumánovics [États-Unis] ; Opal S. Chen ; Liangtao Li ; Dustin Bagley ; Erika M. Adkins ; Huilan Lin ; Nin N. Dingra ; Caryn E. Outten ; Greg Keller ; Dennis Winge ; Diane M. Ward ; Jerry Kaplan

Source :

The Journal of biological chemistry [ 0021-9258 ] ; 2008.

RBID : pubmed:18281282

Descripteurs français

English descriptors

KwdEn :
- Active Transport, Cell Nucleus (MeSH), Cell Nucleus (metabolism), Cytosol (metabolism), Fungal Proteins (chemistry), Gene Deletion (MeSH), Genetic Complementation Test (MeSH), Intracellular Signaling Peptides and Proteins (metabolism), Iron (metabolism), Iron-Sulfur Proteins (chemistry), Mitochondria (metabolism), Models, Biological (MeSH), Models, Genetic (MeSH), Mutation (MeSH), Plasmids (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (metabolism), Transcription, Genetic (MeSH).
MESH :
- chemical , chemistry : Fungal Proteins, Iron-Sulfur Proteins.
- genetics : Saccharomyces cerevisiae.
- metabolism : Cell Nucleus, Cytosol, Intracellular Signaling Peptides and Proteins, Iron, Mitochondria, Plasmids, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins.
- Active Transport, Cell Nucleus, Gene Deletion, Genetic Complementation Test, Models, Biological, Models, Genetic, Mutation, Transcription, Genetic.

Abstract

The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the iron transport system in Saccharomyces cerevisiae is not known. Using a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a complex that interprets the signal derived from mitochondrial Fe-S synthesis. We found that mutations in FRA1 (YLL029W) and FRA2 (YGL220W) led to an increase in transcription of the iron regulon. In cells incubated in high iron medium, deletion of either FRA gene results in the translocation of the low iron-sensing transcription factor Aft1 into the nucleus, where it occupies the FET3 promoter. Deletion of either FRA gene has the same effect on transcription as deletion of both genes and is not additive with activation of the iron regulon due to loss of mitochondrial Fe-S cluster synthesis. These observations suggest that the FRA proteins are in the same signal transduction pathway as Fe-S cluster synthesis. We show that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion. The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion. These results show that the Fra-Grx complex is an intermediate between the production of mitochondrial Fe-S clusters and transcription of the iron regulon.

DOI: 10.1074/jbc.M801160200
PubMed: 18281282
PubMed Central: PMC2447656

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000C14
to stream Main, to step Curation: 000C14

Le document en format XML

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<term>Cell Nucleus (metabolism)</term>
<term>Cytosol (metabolism)</term>
<term>Fungal Proteins (chemistry)</term>
<term>Gene Deletion (MeSH)</term>
<term>Genetic Complementation Test (MeSH)</term>
<term>Intracellular Signaling Peptides and Proteins (metabolism)</term>
<term>Iron (metabolism)</term>
<term>Iron-Sulfur Proteins (chemistry)</term>
<term>Mitochondria (metabolism)</term>
<term>Models, Biological (MeSH)</term>
<term>Models, Genetic (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Plasmids (metabolism)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Transcription, Genetic (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cytosol (métabolisme)</term>
<term>Délétion de gène (MeSH)</term>
<term>Fer (métabolisme)</term>
<term>Ferrosulfoprotéines (composition chimique)</term>
<term>Mitochondries (métabolisme)</term>
<term>Modèles biologiques (MeSH)</term>
<term>Modèles génétiques (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Plasmides (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Protéines et peptides de signalisation intracellulaire (métabolisme)</term>
<term>Protéines fongiques (composition chimique)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Test de complémentation (MeSH)</term>
<term>Transcription génétique (MeSH)</term>
<term>Transport nucléaire actif (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fungal Proteins</term>
<term>Iron-Sulfur Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Ferrosulfoprotéines</term>
<term>Protéines fongiques</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term>
<term>Cytosol</term>
<term>Intracellular Signaling Peptides and Proteins</term>
<term>Iron</term>
<term>Mitochondria</term>
<term>Plasmids</term>
<term>Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytosol</term>
<term>Fer</term>
<term>Mitochondries</term>
<term>Noyau de la cellule</term>
<term>Plasmides</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines et peptides de signalisation intracellulaire</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term>
<term>Gene Deletion</term>
<term>Genetic Complementation Test</term>
<term>Models, Biological</term>
<term>Models, Genetic</term>
<term>Mutation</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Délétion de gène</term>
<term>Modèles biologiques</term>
<term>Modèles génétiques</term>
<term>Mutation</term>
<term>Test de complémentation</term>
<term>Transcription génétique</term>
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<front><div type="abstract" xml:lang="en">The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the iron transport system in Saccharomyces cerevisiae is not known. Using a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a complex that interprets the signal derived from mitochondrial Fe-S synthesis. We found that mutations in FRA1 (YLL029W) and FRA2 (YGL220W) led to an increase in transcription of the iron regulon. In cells incubated in high iron medium, deletion of either FRA gene results in the translocation of the low iron-sensing transcription factor Aft1 into the nucleus, where it occupies the FET3 promoter. Deletion of either FRA gene has the same effect on transcription as deletion of both genes and is not additive with activation of the iron regulon due to loss of mitochondrial Fe-S cluster synthesis. These observations suggest that the FRA proteins are in the same signal transduction pathway as Fe-S cluster synthesis. We show that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion. The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion. These results show that the Fra-Grx complex is an intermediate between the production of mitochondrial Fe-S clusters and transcription of the iron regulon.</div>
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<Abstract><AbstractText>The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the iron transport system in Saccharomyces cerevisiae is not known. Using a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a complex that interprets the signal derived from mitochondrial Fe-S synthesis. We found that mutations in FRA1 (YLL029W) and FRA2 (YGL220W) led to an increase in transcription of the iron regulon. In cells incubated in high iron medium, deletion of either FRA gene results in the translocation of the low iron-sensing transcription factor Aft1 into the nucleus, where it occupies the FET3 promoter. Deletion of either FRA gene has the same effect on transcription as deletion of both genes and is not additive with activation of the iron regulon due to loss of mitochondrial Fe-S cluster synthesis. These observations suggest that the FRA proteins are in the same signal transduction pathway as Fe-S cluster synthesis. We show that Fra1 and Fra2 interact in the cytosol in an iron-independent fashion. The Fra1-Fra2 complex binds to Grx3 and Grx4, two cytosolic monothiol glutaredoxins, in an iron-independent fashion. These results show that the Fra-Grx complex is an intermediate between the production of mitochondrial Fe-S clusters and transcription of the iron regulon.</AbstractText>
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Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

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